Parameter Set Neuroleptics 1/EXTENDED - LC-MS/MS

Clinical relevance

Neuroleptic agents, also known as antipsychotics, are used to treat psychosis and other psychological disorders such as severe manic depressive conditions accompanied by delusions and hallucinations. Their effect is based on influencing the synaptic conduction in the central nervous system. The neuroleptics bind to specific receptors of the neurotransmitters such as dopamine, preventing transmission of stimulus information and leading to inhibition of the transmission of neural signals.

To avoid interferences and to enable an accurate analysis, the neuroleptics are divided into two Parameter Sets, Neuroleptics 1/EXTENDED and Neuroleptics 2/EXTENDED 2. The present analysis set Neuroleptics 1/EXTENDED has been extended by the metabolites norquetiapine and dehydroaripiprazole.

Product advantages

With the Parameter Set Neuroleptics 1/EXTENDED in serum/plasma, 11 different analytes can be measured fast and efficiently using LC-MS/MS. Due to the careful optimisation of all kit components as well as the chromatographic separation, matrix effects (“ion suppression”) are minimised and the robustness of the method is enhanced. Sample preparation is based on a protein precipitation step. The use of stable isotopically labelled (deuterated) and co-eluting internal standards as well as 3PLUS1® multilevel calibrators ensures high precision and reproducible and reliable quantification of the analytes. The method is comprehensively validated.

The Parameter Set is a part of the Series A modular system, which enables the analysis of all parameters without switching column or changing the mobile phases, thereby minimising required workload in the laboratory. The Basic Kit A contains all components required for sample preparation and all necessary mobile phases. The MasterColumn® A is the analytical column used for the determination of all Series A analytes. Our portfolio contains further MassTox® Parameter Sets.

For the analysis you require the MassTox® TDM Basic Kit A, the specific MassTox® TDM Parameter Set and the analytical column MassTox® TDM MasterColumn® A.